TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0

被引：255

作者：

Pedruzzi, I

Dubouloz, F

Cameroni, E

Wanke, V

Roosen, J

Winderickx, J

De Virgilio, C ^{[1
]}

机构：

[1] Univ Geneva, Dept Biochem Med, CMU, CH-1211 Geneva 4, Switzerland

[2] Katholieke Univ Leuven, B-3001 Heverlee, Belgium

来源：

MOLECULAR CELL | 2003年 / 12卷 / 06期

关键词：

D O I：

10.1016/S1097-2765(03)00485-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly conserved Tor kinases (TOR) and the protein kinase A (PKA) pathway regulate cell proliferation in response to growth factors and/or nutrients. In Saccharomyces cerevisiae, loss of either TOR or PKA causes cells to arrest growth early in G(1) and to enter G(0) by mechanisms that are poorly understood. Here we demonstrate that the protein kinase Rim15 is required for entry into G(0) following inactivation of TOR and/or PKA. Induction of Rim15-dependent G(0) traits requires two discrete processes, i.e., nuclear accumulation of Rim15, which is negatively regulated both by a Sit4-independent TOR effector branch and the protein kinase B (PKB/Akt) homolog Sch9, and release from PKA-mediated inhibition of its protein kinase activity. Thus, Rim15 integrates signals from at least three nutrient-sensory kinases (TOR, PKA, and Sch9) to properly control entry into G(0), a key developmental process in eukaryotic cells.

引用

页码：1607 / 1613

页数：7

共 29 条

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