All is fair in virus-host interactions: NK cells and cytomegalovirus

被引：49

作者：

Babic, Marina ^{[1
]}

Krmpotic, Astrid ^{[1
]}

Jonjic, Stipan ^{[1
]}

机构：

[1] Univ Rijeka, Fac Med, Dept Histol & Embryol, Rijeka 51000, Croatia

来源：

TRENDS IN MOLECULAR MEDICINE | 2011年 / 17卷 / 11期

关键词：

NATURAL-KILLER-CELLS; MURINE CYTOMEGALOVIRUS; FUNCTIONAL-ANALYSIS; RECEPTOR; RECOGNITION; MICRORNAS; RESPONSES; LY49; RESISTANCE; COMPLEX;

D O I：

10.1016/j.molmed.2011.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The infection of mice with mouse cytomegalovirus (MCMV) as a model of human cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. Millions of years of co-evolution between cytomegaloviruses (CMV) and their hosts has resulted in numerous attempts to overwhelm each other. CMVs devote many genes to modulating the host natural killer (NK) cell response and NK cells employ many strategies to cope with CMV infection. While focusing on these attack-counterattack measures, this review will discuss several novel mechanisms of immune evasion by MCMV, the role of Ly49 receptors in mediating resistance to MCMV, and the impact of the initial NK cell response on the shaping of adaptive immunity.

引用

页码：677 / 685

页数：9

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