Recent progress in the development of assays suited for histone deacetylase inhibitor screening

被引：26

作者：

Wegener, D ^{[1
]}

Hildmann, C ^{[1
]}

Schwienhorst, A ^{[1
]}

机构：

[1] Inst Mikrobiol & Genet, Abt Mol Genet & Praeparat Mol Biol, D-37077 Gottingen, Germany

来源：

MOLECULAR GENETICS AND METABOLISM | 2003年 / 80卷 / 1-2期

关键词：

D O I：

10.1016/j.ymgme.2003.08.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Histone deacetylase (HDAC) inhibitors have an unprecedented potential to occupy a major position in the future market of anticancer agents. However, progress in the development of these new chemotherapeutics is largely dependent on the existence of bioassays well-suited for inhibitor screening. Herein, we summarize recent developments in HDAC assay technology and, particularly, discuss different assay types with respect to their suitability for high-throughput screening programs. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：138 / 147

页数：10

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