Synthesis and characterization of poly(ethylene glycol) dimethacrylate hydrogels

被引：21

作者：

Lin-Gibson, S ^{[1
]}

Bencherif, S

Antonucci, JM

Jones, RL

Horkay, F

机构：

[1] Natl Inst Stand & Technol, Div Polymers, Gaithersburg, MD 20899 USA

[2] NICHD, Sect Tissue Biophys & Biomimet, Lab Integrat & Med Biophys, NIH, Bethesda, MD 20892 USA

来源：

MACROMOLECULAR SYMPOSIA | 2005年 / 227卷

关键词：

gel structure; hydrogel; MALDI-TOF MS; mechanical properties; neutron scattering; poly(ethylene glycol); SANS;

D O I：

10.1002/masy.200550924

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Facile synthesis and detailed characterization of photopolymerizable and biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) and their hydrogels are described. Combined analyses of H-1 NMR and MALDI-TOF MS confirmed the formation of prepolymers of high purity and narrow mass distribution (PD < 1.02). A systematic investigation into the structure and mechanical properties of PEGDM hydrogels was performed to characterize the relationships between the network structure and get properties. Small-angle neutron scattering was used to characterize the structural features of hydrogels with respect to their semidilute solution precursors. A well-defined structural length scale (correlation length) manifested as a maximum in the scattering intensity was observed for hydrogels derived from high molecular mass PEGDMs and/or high oligomer mass fractions. Hydrogels derived from lower molecular mass PEGDMs and/or low oligomer mass fractions exhibited multiple correlation lengths suggesting the formation of inhomogeneous gel structures. The shear moduli, determined from uniaxial compression measurement, showed that the gel structures correlate well with the gel mechanical properties.

引用

页码：243 / 254

页数：12

共 14 条

[1] Photopolymerization kinetics of multifunctional monomers [J].

Andrzejewska, E .

PROGRESS IN POLYMER SCIENCE, 2001, 26 (04) :605-665

[2] Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels [J].

Bryant, SJ ;

Anseth, KS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (01) :63-72

[3] Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage [J].

Bryant, SJ ;

Anseth, KS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 64A (01) :70-79

[4]

Elisseeff J, 2000, J BIOMED MATER RES, V51, P164, DOI 10.1002/(SICI)1097-4636(200008)51:2<164::AID-JBM4>3.3.CO

[5]

2-N

[6] NIST-sponsored interlaboratory comparison of polystyrene molecular mass distribution obtained by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: Statistical analysis [J].

Guttman, CM ;

Wetzel, SJ ;

Blair, WR ;

Fanconi, BM ;

Girard, JE ;

Goldschmidt, RJ ;

Wallace, WE ;

VanderHart, DL .

ANALYTICAL CHEMISTRY, 2001, 73 (06) :1252-1262

[7] Cytotoxicity of denture base acrylic resins: A literature review [J].

Jorge, JH ;

Giampaolo, ET ;

Machado, AL ;

Vergani, CE .

JOURNAL OF PROSTHETIC DENTISTRY, 2003, 90 (02) :190-193

[8] LIGHT AND NEUTRON-SCATTERING STUDIES OF EXCESS LOW-ANGLE SCATTERING IN MODERATELY CONCENTRATED POLYSTYRENE SOLUTIONS [J].

KOBERSTEIN, JT ;

PICOT, C ;

BENOIT, H .

POLYMER, 1985, 26 (05) :673-681

[9] Synthesis and characterization of PEG dimethacrylates and their hydrogels [J].

Lin-Gibson, S ;

Bencherif, S ;

Cooper, JA ;

Wetzel, SJ ;

Antonucci, JM ;

Vogel, BM ;

Horkay, F ;

Washburn, NR .

BIOMACROMOLECULES, 2004, 5 (04) :1280-1287

[10] Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering [J].

Mann, BK ;

Gobin, AS ;

Tsai, AT ;

Schmedlen, RH ;

West, JL .

BIOMATERIALS, 2001, 22 (22) :3045-3051

← 1 2 →