Optimising management of hypertension in primary care: The Valsartan Intensified Primary Care Reduction of Blood Pressure (Viper-Bp) Study

被引:8
作者
Stewart, Simon [1 ]
Carrington, Melinda J. [1 ]
Swemmer, Carla
Kurstjens, Nicol
Jennings, Garry L. [1 ]
机构
[1] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
Hypertension; Anti-hypertensive treatment; Management and control; Disease management; Cardiovascular risk; AUSTRALIAN ADULTS; OUTCOMES;
D O I
10.1016/j.ijcard.2010.12.055
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The Valstartan Intensified Primary CarE Reduction of Blood Pressure Study (VIPER-BP) Study is an open-label, randomised controlled trial comparing usual primary care management with an intensive BP management strategy using three forms of valsartan-based therapy (mono-therapy, thiazide diuretic or calcium channel blocker combinations) to achieve individualised BP control. Methods: To identify the features of General Practitioner (GP) management of hypertension in Australia, we analyse the response to a case scenario-based survey of 500 GPs. We subsequently recruited a national cohort of GP Investigators to enrol up to 2500 patients into the VIPER-BP Study. Results: GP responses clearly demonstrated that, compared to the VIPER-BP intervention, a heterogeneous approach to the primary care management of hypertension persists in Australia. By November 2010, 2157 hypertensive patients from 272 actively recruiting GP Investigators were enrolled into the study. Of these, 1965 (91%) patients were entered into a standardised "run-in" phase of 28 days of valsartan 80 mg/day. Subsequently, 1285 patients were randomised to usual care (n=435) or the VIPER-BP intervention (n=850). There was a predominance of males (62%), whilst 55% had pre-existing diabetes or cardiovascular disease and 63% had been previously treated for hypertension. Mean systolic and diastolic BP on randomisation for men and women, respectively, was 148 +/- 15/88 +/- 11 and 148 +/- 18/87 +/- 10 mm Hg. Conclusions: In contrast to typical primary care management of hypertension, VIPER-BP combines more intensive and aggressive therapies with structured management to more rapidly attain and sustain individualised BP targets in hypertensive patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:317 / 322
页数:6
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