Efficacy of caspofungin against Aspergillus terreus

被引：12

作者：

Barchiesi, F

Spreghini, E

Santinelli, A

Fothergill, AW

Fallani, S

Manso, E

Pisa, E

Giannini, D

Novelli, A

Cassetta, MI

Mazzei, T

Rinaldi, MG

Scalise, G

机构：

[1] Univ Policlin Marche, Ist Malattie Infett & Med Pubbl, Azienda Osped Univ, Osped Riuniti Umberto I Lancisi Salesi, I-60020 Ancona, Italy

[2] Univ Policlin Marche, Ist Anat Patol, I-60020 Ancona, Italy

[3] Univ Policlin Marche, Ctr Gest Presidenza Med & Chirurg, I-60020 Ancona, Italy

[4] Univ Osped Riuniti Umberto I Lancisi Salesi, Microbiol Lab, Ancona, Italy

[5] Univ Florence, Ist Farmacol Preclin & Clin, Florence, Italy

[6] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA

[7] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 12期

关键词：

D O I：

10.1128/AAC.49.12.5133-5135.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.

引用

页码：5133 / 5135

页数：3

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