Hyperhomocysteinemia in dementia

被引：113

作者：

Leblhuber, F

Walli, J

Artner-Dworzak, E

Vrecko, K

Widner, B

Reibnegger, G

Fuchs, D

机构：

[1] Landesnervenklin Wagner Jauregg, Dept Gerontol, A-4020 Linz, Austria

[2] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria

[3] Graz Univ, Inst Med Chem, A-8010 Graz, Austria

来源：

JOURNAL OF NEURAL TRANSMISSION | 2000年 / 107卷 / 12期

关键词：

homocysteine; dementia; Alzheimer's disease; vascular dementia; folic acid;

D O I：

10.1007/s007020070010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.

引用

页码：1469 / 1474

页数：6

共 13 条

[1] Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease [J].

Clarke, R ;

Smith, AD ;

Jobst, KA ;

Refsum, H ;

Sutton, L ;

Ueland, PM .

ARCHIVES OF NEUROLOGY, 1998, 55 (11) :1449-1455

[2] Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. A prospective cohort study [J].

De Jong, SC ;

Stehouwer, CDA ;

Van den Berg, M ;

Geurts, TW ;

Bouter, LM ;

Rauwerda, JA .

JOURNAL OF INTERNAL MEDICINE, 1999, 246 (01) :87-96

[3] Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease [J].

Gottfries, CG ;

Lehmann, W ;

Regland, B .

JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (8-9) :773-786

[4] Homocysteine and vascular disease [J].

Hankey, GJ ;

Eikelboom, JW .

LANCET, 1999, 354 (9176) :407-413

[5] Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study [J].

Hofman, A ;

Ott, A ;

Breteler, MMB ;

Bots, ML ;

Slooter, AJC ;

vanHarskamp, F ;

vanDuijn, CN ;

Van Broeckhoven, C ;

Grobbee, DE .

LANCET, 1997, 349 (9046) :151-154

[6]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[7] Homocysteine and cardiovascular disease [J].

Refsum, H ;

Ueland, PM ;

Nygård, O ;

Vollset, SE .

ANNUAL REVIEW OF MEDICINE, 1998, 49 :31-62

[8] VASCULAR DEMENTIA - DIAGNOSTIC-CRITERIA FOR RESEARCH STUDIES - REPORT OF THE NINDS-AIREN INTERNATIONAL WORKSHOP [J].

ROMAN, GC ;

TATEMICHI, TK ;

ERKINJUNTTI, T ;

CUMMINGS, JL ;

MASDEU, JC ;

GARCIA, JH ;

AMADUCCI, L ;

ORGOGOZO, JM ;

BRUN, A ;

HOFMAN, A ;

MOODY, DM ;

OBRIEN, MD ;

YAMAGUCHI, T ;

GRAFMAN, J ;

DRAYER, BP ;

BENNETT, DA ;

FISHER, M ;

OGATA, J ;

KOKMEN, E ;

BERMEJO, F ;

WOLF, PA ;

GORELICK, PB ;

BICK, KL ;

PAJEAU, AK ;

BELL, MA ;

DECARLI, C ;

CULEBRAS, A ;

KORCZYN, AD ;

BOGOUSSLAVSKY, J ;

HARTMANN, A ;

SCHEINBERG, P .

NEUROLOGY, 1993, 43 (02) :250-260

[9]

Sattler W, 1999, PTERIDINES, V10, P220

[10]

Selhub J, 2000, AM J CLIN NUTR, V71, p614S

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