Tissue factor, the blood, and the arterial wall

被引：94

作者：

Rauch, U ^{[1
]}

Nemerson, Y ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Thrombosis Res, New York, NY 10029 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S1050-1738(00)00049-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombogenic tissue factor (TF) on cell-derived microparticles is present in the circulating blood of patients with acute coronary syndromes. Recently, we reported that leukocytes transfer TF-positive particles to platelet thrombi, making them capable of triggering and propagating thrombus growth. This observation changes the original dogma that vessel-wall injury and exposure of tissue factor within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF-positive leukocyte particles is dependent on the interaction of CD15 and TF with platelet thrombi. The inhibition of TF transfer and TF activity suggests a novel therapeutic approach to the prevention of thrombosis that may prove to be effective in disorders associated with increased blood TF. (Trends Cardiovasc Med 2000;10:139-143). (C) 2001 Elsevier Science Inc.

引用

页码：139 / 143

页数：5

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