Inactivation of NF-κB involved in osteoblast development through interleukin-6

被引：13

作者：

Deyama, Y ^{[1
]}

Takeyama, S ^{[1
]}

Suzuki, K ^{[1
]}

Yoshimura, Y ^{[1
]}

Nishikata, M ^{[1
]}

Matsumoto, A ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Pathobiol Sci, Sapporo, Hokkaido 0608586, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 282卷 / 05期

关键词：

NF-kappa B; p50; osteoblast development; interleukin-6;

D O I：

10.1006/bbrc.2001.4693

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteoblasts undergo a process of proliferation and differentiation and are responsible for hone formation. In this study, we examined the relation between NF-kappaB, a key transcription factor in bone metabolism, and osteoblast maturation. NF-kappaB activity and expression of p50, a subunit of NF-kappaB, decreased during development of osteoblastic MC3T3-E1 cells. The secretion of IL-6 by osteoblast, which in combination with soluble IL-6 receptor induces conversion of fibroblasts to alkaline phosphatase-positive cells, also increased. p50 antisense oligonucleotide increased IL-6 mRNA expression. These results suggest that p50 regulates transcription of IL-6 and indirectly controls osteoblast maturation. (C) 2001 Academic Press.

引用

页码：1080 / 1084

页数：5

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