Association of severe haemophilia A and factor V Leiden: Report of three cases

被引：26

作者：

Arruda, VR ^{[1
]}

AnnichinoBizzacchi, JM ^{[1
]}

Antunes, SV ^{[1
]}

Costa, FF ^{[1
]}

机构：

[1] ESOLA PAULISTA MED,SCH MED,DEPT INTERNAL MED,SAO PAULO,BRAZIL

来源：

HAEMOPHILIA | 1996年 / 2卷 / 01期

关键词：

haemophilia; factor V gene; thrombosis; hypercoagulability;

D O I：

10.1111/j.1365-2516.1996.tb00011.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical severity of haemophilia is usually related to residual clotting factor activity. Reports of factor V deficiency or protein C have been described in haemophilic patients and both are involved in the activated protein C pathway. Recently, the poor response to activated protein C due to factor V Leiden (FQ506) has been associated with an increased risk of thrombosis and its incidence in the normal population is given as 2-7%. We describe three cases of severe haemophilia A heterozygous for factor V Leiden and its influence on phenotype.

引用

页码：51 / 53

页数：3

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