Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy

被引:51
作者
Meythaler, JM
Guin-Renfroe, S
Law, C
Grabb, P
Hadley, MN
机构
[1] Univ Alabama Birmingham, Spain Rehabil Ctr R157, Dept Phys Med & Rehabil, Sch Med, Birmingham, AL 35233 USA
[2] Univ Alabama Birmingham, Sch Med, Div Neurol Surg, Birmingham, AL 35233 USA
来源
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | 2001年 / 82卷 / 02期
关键词
adolescents; adults; baclofen; cerebral palsy; dystonia; muscle hypertonia; muscle spasticity; rehabilitation;
D O I
10.1053/apmr.2001.19246
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To determine if the continuous intrathecal delivery of baclofen will control spastic hypertonia caused by longstanding cerebral palsy (CP). Design: Case series. Setting: Tertiary care outpatient and inpatient rehabilitation center directly attached to a university hospital. Patients: Thirteen CP patients (average age, 25yr; range, 13-43yr) with intractable spastic hypertonia and quadriparesis (one of whom had predominate diplegia) who had not responded to oral medications including baclofen. Intervention: patients were screened via a bolus injection of baclofen intrathecally. Those who dropped an average of 2 points on their lower extremity (LE) Ashworth scores were offered computer-controlled pump implantation for 12 months of continuous delivery of intrathecal baclofen (ITB). Main Outcome Measures: Ashworth rigidity scores, spasm scores, and deep tendon reflex scores were collected for both the upper extremities (UEs) and LEs. Differences over time were assessed via descriptive statistics and Wilcoxon's signed-rank test. Results: After 1 year of continuous ITB treatment, the average LE Ashworth score +/- standard deviation decreased from 3.4 +/- 1.2. to 1.5 +/- 0.7 (p < .0001), spasm score from 1.4 +/- 1.6 to 0.6 +/- 1.2 (p = .1024), and reflex score from 2.5 +/- 1.2 to 0.7 +/- 1.0 (p < .0001). The average UE Ashworth score decreased from 3.0 +/- 1.2 to 1.7 +/- 1.0 (p < .0001), spasm score from 1.2 +/- 1.6 to 0.2 +/- 0.6 (p = .0135), and reflex score from 2.3 +/- 0.7 to 0.5 +/- 0.9 (1, < .0001), The average ITB dose required to attain these effects at 1 year was 263 +/- 91 mug continuously infused per day. Conclusion: Continuously infused ITB can reduce spastic hypertonia in the UEs and LEs associated with long-standing CP. This reduction in tone will allow more freedom of movement and the potential for improved function.
引用
收藏
页码:155 / 161
页数:7
相关论文
共 43 条
[1]   Continuous intrathecal baclofen infusion for symptomatic generalized dystonia [J].
Albright, AL ;
Barry, MJ ;
Fasick, P ;
Barron, W ;
Shultz, B .
NEUROSURGERY, 1996, 38 (05) :934-938
[2]   CONTINUOUS INTRATHECAL BACLOFEN INFUSION FOR SPASTICITY OF CEREBRAL ORIGIN [J].
ALBRIGHT, AL ;
BARRON, WB ;
FASICK, MP ;
POLINKO, P ;
JANOSKY, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (20) :2475-2477
[3]  
ALBRIGHT LA, 1997, INTRATHECAL BACLOFEN
[4]  
[Anonymous], GUIDELINES MANAGEMEN
[5]   SEGMENTAL REFLEX PATHWAYS IN SPINAL SHOCK AND SPINAL SPASTICITY IN MAN [J].
ASHBY, P ;
VERRIER, M ;
LIGHTFOOT, E .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1974, 37 (12) :1352-1360
[6]  
ASHWORTH B, 1964, PRACTITIONER, V192, P540
[7]   Continuous intrathecal baclofen infusion in severe spasticity after traumatic or hypoxic brain injury [J].
Becker, R ;
Alberti, O ;
Bauer, BL .
JOURNAL OF NEUROLOGY, 1997, 244 (03) :160-166
[8]   INTRATHECAL BACLOFEN FOR INTRACTABLE SPASTICITY OF SPINAL ORIGIN - RESULTS OF A LONG-TERM MULTICENTER STUDY [J].
COFFEY, RJ ;
CAHILL, D ;
STEERS, W ;
PARK, TS ;
ORDIA, J ;
MEYTHALER, J ;
HERMAN, R ;
SHETTER, AG ;
LEVY, R ;
GILL, B ;
SMITH, R ;
WILBERGER, J ;
LOESER, JD ;
CHABAL, C ;
FELER, C ;
ROBERTSON, JT ;
PENN, RD ;
CLARKE, A ;
BURCHIEL, KJ ;
LEIBROCK, LG .
JOURNAL OF NEUROSURGERY, 1993, 78 (02) :226-232
[9]  
DELUCA PA, 1990, CLIN ORTHOPAEDICS, V264, P65
[10]   Use of intrathecal baclofen in the treatment of patients with dystonia [J].
Ford, B ;
Greene, P ;
Louis, ED ;
Petzinger, G ;
Bressman, SB ;
Goodman, R ;
Brin, MF ;
Sadiq, S ;
Fahn, S .
ARCHIVES OF NEUROLOGY, 1996, 53 (12) :1241-1246