Structure of the mouse calpain small subunit gene

被引：16

作者：

Arthur, JSC

Greer, PA

Elce, JS ^{[1
]}

机构：

[1] Queens Univ, Dept Biochem, Kingston, ON K7L 3N6, Canada

[2] Queens Univ, Dept Pathol, Kingston, ON K7L 3N6, Canada

[3] Queens Univ, Canc Res Lab, Kingston, ON K7L 3N6, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY | 1998年 / 1388卷 / 01期

基金：

英国医学研究理事会;

关键词：

calpain; small subunit; cDNA; gene; (mouse);

D O I：

10.1016/S0167-4838(98)00166-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The calpains comprise a family of heterodimeric (80+28 kDa) Ca2+-dependent cysteine proteases, probably having roles in signal transduction and cytoskeletal remodelling. We describe cloning and sequencing of the 28 kDa calpain subunit cDNA from mouse (coding for 268 amino acids), and characterization of its gene. The gene spans 7 kb and contains 11 exons. The promoter region, like those of other calpain genes, lacks an obvious TATA box, but contains several Spl binding sites. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：247 / 252

页数：6

共 19 条

[1] Investigation of the interaction of m-calpain with phospholipids: Calpain-phospholipid interactions [J].