Degradation of luteinizing hormone releasing hormone in buccal, liver, nasal and skin tissues

被引：10

作者：

Bi, M ^{[1
]}

Singh, J ^{[1
]}

机构：

[1] N Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Fargo, ND 58105 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 175卷 / 02期

关键词：

degradation rate; LHRH; enzymatic barrier; intact tissue; tissue homogenate; HPLC;

D O I：

10.1016/S0378-5173(98)00291-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Degradation of luteinizing hormone releasing hormone (LHRH) in various pig tissues (i.e. buccal, liver, nasal and skin) and in their corresponding homogenates was determined. The degradation of LHRH followed apparent first-order kinetics. The degradation rates of LHRH in intact tissues were lower than in their corresponding homogenates. The lowest degradation rate [(0.15 +/- 0.01) x 10(3) min(-1)] was observed in intact skin tissue indicating that the skin has minimal proteolytic activity, thus decreasing the rate of LHRH degradation. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：269 / 273

页数：5

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