The folate receptor as a molecular target for tumor-selective radionuclide delivery

被引：71

作者：

Ke, CY ^{[1
]}

Mathias, CJ ^{[1
]}

Green, MA ^{[1
]}

机构：

[1] Purdue Univ, Dept Ind & Phys Pharm, Div Nucl Pharm, W Lafayette, IN 47907 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2003年 / 30卷 / 08期

关键词：

folate receptor; folate binding protein; tumor targeting; radiopharmaceutical; radionuclide imaging;

D O I：

10.1016/S0969-8051(03)00117-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：811 / 817

页数：7

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