Zr-Ti-Nb porous alloys for biomedical application

被引：59

作者：

Aguilar Maya, A. E. ^{[2
]}

Grana, D. R. ^{[1
]}

Hazarabedian, A. ^{[2
]}

Kokubu, G. A. ^{[1
]}

Luppo, M. I. ^{[1
,2
]}

Vigna, G. ^{[1
]}

机构：

[1] Univ El Salvador, Sch Dent, Fac Med, Argentina Assoc Odontol, Buenos Aires, DF, Argentina

[2] Argentina Atom Energy Commiss, Dept Mat, Buenos Aires, DF, Argentina

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 02期

关键词：

Porous materials; Biomaterials; Powder metallurgy; Ti-Zr alloys; Biocompatibility; BONE; TITANIUM; HYDROXYAPATITE; SUBSTITUTE; MICROSCOPY; SCAFFOLD; METALS; DEFECT; FOAMS;

D O I：

10.1016/j.msec.2011.10.035

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Recent studies linked to the production of implants focus on the development of porous materials, as they provide good biological fixation to the surrounding tissue through bone tissue ingrowth into the porous network. Research on the biological behavior of metals has shown that the composition of implant biomaterials must be carefully selected to avoid adverse reactions. Ti, Zr and Nb are non-toxic metals with a good compatibility. In the present study, Zr-Ti-Nb foams of two compositions (Zr-34.4%Ti-1.6%Nb and Zr-34.5%Ti-5.5%Nb) were fabricated starting from hydride-dehydride powdered metal using space-holding fillers. Both foams displayed an interconnected porous structure with a porosity of 70%. The average pore size was around 260 mu m. The Young's modulus and the compressive plateau stress were observed to vary with the Nb content in the range of 0.3-1.4 GPa and 11-32 MPa, respectively. All alloys tested - in porous and solid forms - showed excellent biocompatibility in subcutaneous as well as in bone tissues. The alloy with more Nb content showed pronounced osteoinductive properties. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：321 / 329

页数：9

共 39 条

[1]

Phase stability change with Zr content in β-type Ti-Nb alloys [J].

Abdel-Hady, Mohamed ;

Fuwa, Hiroki ;

Hinoshita, Keita ;

Kimura, Haruka ;

Shinzato, Yoshifumi ;

Morinaga, Masahiko .

SCRIPTA MATERIALIA, 2007, 57 (11) :1000-1003

[2]

Manufacture, characterisation and application of cellular metals and metal foams [J].

Banhart, J .

PROGRESS IN MATERIALS SCIENCE, 2001, 46 (06) :559-U3

[3]

Titanium compacts produced by the pulvimetallurgical hydride-dehydride method for biomedical applications [J].

Barreiro, M. M. ;

Grana, D. R. ;

Kokubu, G. A. ;

Luppo, M. I. ;

Mintzer, S. ;

Vigna, G. .

BIOMEDICAL MATERIALS, 2010, 5 (02)

[4]

Synthetic hydroxyapatite as bone substitute in the experimentally caused defect on the dog tibia proximal third: electronic transmission microscopy aspects [J].

Borges, APB ;

Rezende, CMF ;

Ribeiro, MFB ;

Melo, EG ;

Neto, PIN .

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA, 2000, 52 (06) :616-620

[5]

*CAN COUNC AN CAR, 1993, GUID CAR US EXPT AN, V2

[6]

Clokie C.M.L., 1995, J ORAL MAXILLOFAC IM, V10, P155

[7]

Davies JE, 1997, J BIOMED MATER RES, V36, P429, DOI 10.1002/(SICI)1097-4636(19970915)36:4<429::AID-JBM1>3.0.CO

[8]

2-G

[9]

Processing of titanium foams using magnesium spacer particles [J].

Esen, Z. ;

Bor, S. .

SCRIPTA MATERIALIA, 2007, 56 (05) :341-344

[10]

Froes F.H., 2001, ADV POWDER METALL PA, P84

← 1 2 3 4 →