Swapping nucleotides, tuning Hsp70

被引：18

作者：

Cyr, Douglas M. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

CELL | 2008年 / 133卷 / 06期

关键词：

D O I：

10.1016/j.cell.2008.05.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular chaperones such as heat shock protein 70 (Hsp70) are crucial for protein folding. Crystal structures of Hsp70 in a complex with the nucleotide exchange factor (NEF) Hsp110 reported in this issue of Cell (Polier et al., 2008) and in Molecular Cell (Schuermann et al., 2008) provide new insights into how NEF action specifies Hsp70 cellular function.

引用

页码：945 / 947

页数：3

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