Long-term follow-up of patients with tuberculosis as a complication of tumour necrosis factor (TNF)-α antagonist therapy:: safe re-initiation of TNF-α blockers after appropriate anti-tuberculous treatment

被引：42

作者：

Denis, B. ^{[1
]}

Lefort, A. ^{[2
]}

Flipo, R. M. ^{[3
]}

Tubach, F. ^{[4
]}

Lemann, M. ^{[5
]}

Ravaud, P. ^{[4
]}

Salmon, D. ^{[6
]}

Mariette, X.

Lortholary, O. ^{[1
,7
]}

机构：

[1] Univ Paris 05, Hop Necker Enfants Malad, Serv Malad Infect & Trop, Ctr Infectiol Necker Pasteur, F-75015 Paris, France

[2] Univ Paris 07, Serv Med Interne, Hop Beaujon, Clichy, France

[3] CHU Lille, Serv Rhumatol, F-59037 Lille, France

[4] Univ Paris 07, Grp Hosp Bichat Claude Bernand, Dept Epidemiol Biostat & Rech Clin, Inst Natl Sante & Rech Medicale U738, F-75221 Paris, France

[5] Univ Paris 07, Hop Saint Louis, Serv Gastroenterol, F-75221 Paris 05, France

[6] Univ Paris 05, Hop Cochin, Serv Med Interne, F-75270 Paris 06, France

[7] Univ Paris 11, Hop Kremlin Bicetre, Serv Rhumatol, Le Kremlin Bicetre, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2008年 / 14卷 / 02期

关键词：

antagonist treatment; mortality rate; Mycobacterium tuberculosis; tuberculosis; tumour necrosis factor (TNF)-alpha;

D O I：

10.1111/j.1469-0691.2007.01891.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study investigated the long-term outcome of patients with tuberculosis (TB) as a complication of tumour necrosis factor (TNF)-alpha blocker therapy. All TB cases (n = 21) complicating TNF-alpha blocker therapy from French university hospitals were collated between January 2000 and September 2002. Outcome was assessed via a postal questionnaire during September 2005. The mortality rate after 4 years was 4.8%, and one patient had relapsed and six (29%) patients had recommenced TNF-alpha antagonist treatment, after appropriate anti-TB therapy, without reactivation. These data support the concept that TNF-alpha antagonists can be restarted in TB patients provided that adequate anti-TB treatment has been completed.

引用

页码：183 / 186

页数：5

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