Topology of protein folding

被引：3

作者：

Chechetkin, VR ^{[1
]}

Lobzin, VV ^{[1
]}

机构：

[1] TRINITI, Dept Theoret, Div Perspect Invest, Troitsk 142092, Moscow Region, Russia

来源：

PHYSICS LETTERS A | 1998年 / 250卷 / 4-6期

关键词：

writhing; twisting; chirality; three-dimensional folding of proteins;

D O I：

10.1016/S0375-9601(98)00771-3

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

It is shown that the topological concepts developed previously for the analysis of conformations for strips, double-stranded DNA helices, or elastic thin rods can fruitfully be applied to the study of tertiary folding for complicated protein structures. The topological characteristics determine the integral chirality of proteins and play an important role in the mechanisms of folding and molecular recognition. (C) 1998 Elsevier Science B.V.

引用

页码：443 / 448

页数：6

共 26 条

[1]

Alberts B., 1983, MOL BIOL CELL

[2]

[Anonymous], 1986, MODERN GEOMETRY METH

[3]

Calugareanu G., 1961, CZECH MATH J, V11, P588

[4] Local rotations, topological invariant for thin rods, and supercoiling of DNA [J].

Chechetkin, VR .

PHYSICS LETTERS A, 1998, 240 (03) :171-176

[5] Topological invariant for thin rods and its applications to conformations of DNA [J].

Chechetkin, VR .

PHYSICS LETTERS A, 1997, 233 (1-2) :151-153

[6] PROTEINS - 1000 FAMILIES FOR THE MOLECULAR BIOLOGIST [J].

CHOTHIA, C .

NATURE, 1992, 357 (6379) :543-544

[7]

Creighton TE, 1993, PROTEINS STRUCTURES

[8] Conformations of linear DNA [J].

Fain, B ;

Rudnick, J ;

Ostlund, S .

PHYSICAL REVIEW E, 1997, 55 (06) :7364-7368

[9]

Flory P. J., 1969, STAT MECH CHAIN MOL

[10] WRITHING NUMBER OF A SPACE CURVE [J].

FULLER, FB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (04) :815-&

← 1 2 3 →