Mild and practical acylation of alcohols with esters or acetic anhydride under distannoxane catalysis

被引：116

作者：

Orita, A ^{[1
]}

Sakamoto, K ^{[1
]}

Hamada, Y ^{[1
]}

Mitsutome, A ^{[1
]}

Otera, J ^{[1
]}

机构：

[1] Okayama Univ Sci, Dept Appl Chem, Okayama 7000005, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 10期

关键词：

D O I：

10.1016/S0040-4020(99)00072-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Distannoxane catalysts effect acylation of alcohols by action of esters and acetic anhydride. In particular, use of enol esters provides an extremely useful method. Primary alcohols are acylated in preference to secondary ones as well as phenol. Both acid- and base-sensitive functional groups remain intact. Especially unique is the discrimination of thio function which is completely tolerant under the present reaction conditions. This method is highly practical since operation Is quite simple. Esters and solvents can be used without purification and no inert atmosphere is necessary. The products can be isolated simply by column chromatography or distillation without aqueous workup. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2899 / 2910

页数：12

共 77 条

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