Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents

被引：119

作者：

Iwasa, K

Moriyasu, M

Tachibana, Y

Kim, HS

Wataya, Y

Wiegrebe, W

Bastow, KF

Cosentino, LM

Kozuka, M

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[3] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[4] Univ Regensburg, Inst Pharm, D-93040 Regensburg, Germany

[5] Biotech Res Labs Inc, Gaithersburg, MD 20877 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0968-0896(01)00154-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents. These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial), 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen atom of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast, anti-HIV activity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium salts. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2871 / 2884

页数：14

共 32 条

[1] ANTIMICROBIAL ACTIVITY OF SOME ISOQUINOLINE ALKALOIDS [J].