Changing the trajectory of cognitive decline?

被引：9

作者：

Albert, Marilyn S. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2007年 / 357卷 / 05期

关键词：

D O I：

10.1056/NEJMcibr073273

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Environmental enrichment or intracranial injection of a histone deacetylase inhibitor results in improved memory function in mice with neurodegeneration.

引用

页码：502 / 503

页数：2

共 5 条

[1] Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition [J].

Arendash, GW ;

Garcia, MF ;

Costa, DA ;

Cracchiolo, JR ;

Wefes, IM ;

Potter, H .

NEUROREPORT, 2004, 15 (11) :1751-1754

[2] Recovery of learning and memory is associated with chromatin remodelling [J].

Andre Fischer ;

Farahnaz Sananbenesi ;

Xinyu Wang ;

Matthew Dobbin ;

Li-Huei Tsai .

Nature, 2007, 447 (7141) :178-182

[3] Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease [J].

Jankowsky, JL ;

Melnikova, T ;

Fadale, DJ ;

Xu, GM ;

Slunt, HH ;

Gonzales, V ;

Younkin, LH ;

Younkin, SG ;

Borchelt, DR ;

Savonenko, AV .

JOURNAL OF NEUROSCIENCE, 2005, 25 (21) :5217-5224

[4] Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice [J].

Lazarov, O ;

Robinson, J ;

Tang, YP ;

Hairston, IS ;

Korade-Mirnics, Z ;

Lee, VMY ;

Hersh, LB ;

Sapolsky, RM ;

Mirnics, K ;

Sisodia, SS .

CELL, 2005, 120 (05) :701-713

[5] Neural consequences of environmental enrichment [J].

van Praag, H ;

Kempermann, G ;

Gage, FH .

NATURE REVIEWS NEUROSCIENCE, 2000, 1 (03) :191-198

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