Nutrient-sensing mechanisms and pathways

被引：920

作者：

Efeyan, Alejo ^{[1
,2
,3
,4
]}

Comb, William C. ^{[1
,2
,3
,4
]}

Sabatini, David M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[4] Seven Cambridge Ctr, Broad Inst, Cambridge, MA 02142 USA

[5] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

NATURE | 2015年 / 517卷 / 7534期

基金：

美国国家卫生研究院;

关键词：

ACTIVATING PROTEIN COMPLEX; GCN2 EIF2-ALPHA KINASE; AMINO-ACID DEPRIVATION; UNCHARGED TRANSFER-RNA; SWEET TASTE RECEPTORS; ADIPOSE-SPECIFIC GENE; RAG GTPASES; INSULIN-RESISTANCE; TUMOR-SUPPRESSOR; SCAP PROTEIN;

D O I：

10.1038/nature14190

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.

引用

收藏

页码：302 / 310

页数：9

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