Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing

被引：41

作者：

Chen, Shao-Jun ^{[1
]}

Cui, Ming-Chao ^{[1
]}

机构：

[1] Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, 888 Yinxian Ave Eastern Sect, Ningbo 315100, Zhejiang, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 04期

关键词：

Danshen; druggability; network pharmacology; salvianolic acid A; target fishing; DRUG DISCOVERY; PACLITAXEL RESISTANCE; NETWORK PHARMACOLOGY; TRANSGELIN; CANCER; PREDICTION; SERVER; CELLS; IDENTIFICATION; MILTIORRHIZAE;

D O I：

10.3390/molecules22040644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine. A systematic overview of its mechanism of action is yet to be performed. In the present study, the druggability of SAA was measured using the TCMSP server, and potential targets of SAA were identified by PharmMapper and DRAR-CPI. Intersecting targets were then assessed by GeneMANIA and GO pathway analysis, and drug-target-pathway networks were constructed to give a visual view. The results showed that SAA has good druggability, and 13 putative protein targets were identified. Network analysis showed that these targets were associated with cancer, metabolism and other physiological processes. In summary, SAA is predicted to target multiple proteins and pathways to form a network that exerts systematic pharmacological effects.

引用

页数：10

共 40 条

[1]

[Anonymous], ALTERNAT MED

[2]

Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells [J].