Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models

被引：32

作者：

Foulongne, V

Walravens, K

Bourg, G

Boschiroli, ML

Godfroid, J

Ramuz, M

O'Callaghan, D

机构：

[1] Fac Med, INSERM U431, F-30900 Nimes, France

[2] Vet & Agrochem Res Ctr, B-1180 Brussels, Belgium

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期

关键词：

D O I：

10.1128/IAI.69.1.547-550.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow tin a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.

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页码：547 / 550

页数：4

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