Why is it so hard to dissociate multivalent antigens from cell-surface antibodies?

被引：27

作者：

Goldstein, B ^{[1
]}

Wofsy, C ^{[1
]}

机构：

[1] UNIV NEW MEXICO,DEPT MATH & STAT,ALBUQUERQUE,NM 87131

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 02期

关键词：

D O I：

10.1016/0167-5699(96)80583-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is often difficult to induce dissociation of multivalent antigens that are bound to cells by surface-associated immunoglobulin (sIg), even when high concentrations of monovalent hapten are used to fill all free binding sites. Here, Byron Goldstein and Carla Wofsy discuss the evidence that this appears to be due to a cellular and propose that a receptor-desensitization process is responsible for the transition of multivalent antigens to a dissociation-resistant state.

引用

页码：77 / 80

页数：4

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