Imprinting of hippocampal metabolism of choline by its availability during gestation: Implications for cholinergic neurotransmission

被引：48

作者：

Blusztajn, JK ^{[1
]}

Cermak, JM ^{[1
]}

Holler, T ^{[1
]}

Jackson, DA ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

acetylcholine; phosphatidyl choline; memory; nutrition;

D O I：

10.1016/S0928-4257(98)80010-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Choline supplementation during the second half of the gestational period in rats permanently improves visuospatial memory. Choline availability during this period also alters the turnover of choline and acetylcholine in the hippocampus in 3-4-week-old animals in a complex pattern consistent with the notion that cholinergic neurotransmission is enhanced by prenatal choline supplementation. ((C)Elsevier, Paris).

引用

页码：199 / 203

页数：5

共 27 条

[1] Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture [J].

Albright, CD ;

Liu, R ;

Bethea, TC ;

DaCosta, KA ;

Salganik, RI ;

Zeisel, SH .

FASEB JOURNAL, 1996, 10 (04) :510-516

[2] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[3] CHOLINE AND CHOLINERGIC NEURONS [J].

BLUSZTAJN, JK ;

WURTMAN, RJ .

SCIENCE, 1983, 221 (4611) :614-620

[4] SYNTHESIS OF ACETYLCHOLINE FROM CHOLINE DERIVED FROM PHOSPHATIDYLCHOLINE IN A HUMAN NEURONAL CELL-LINE [J].

BLUSZTAJN, JK ;

LISCOVITCH, M ;

RICHARDSON, UI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5474-5477

[5]

BLUSZTAJN JK, 1989, PHOSPHOLIPIDS NERVOU, P205

[6] Prenatal availability of choline modifies development of the hippocampal cholinergic system [J].

Cermak, JM ;

Holler, T ;

Jackson, DA ;

Blusztajn, JK .

FASEB JOURNAL, 1998, 12 (03) :349-357

[7]

*DOOD NUTR BOARD I, DIET REF INT THIAM R

[8] THE MINIMUM VITAMIN REQUIREMENTS OF THE L-CELLS AND HELA CELLS IN TISSUE CULTURE, THE PRODUCTION OF SPECIFIC VITAMIN DEFICIENCIES, AND THEIR CURE [J].

EAGLE, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1955, 102 (05) :595-&

[9] SPATIAL-LEARNING - THE LTP-MEMORY CONNECTION [J].

EICHENBAUM, H .

NATURE, 1995, 378 (6553) :131-132

[10] RAPID RADIOCHEMICAL METHOD FOR DETERMINATION OF CHOLINE-ACETYLTRANSFERASE [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) :407-409

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