Imprinting of hippocampal metabolism of choline by its availability during gestation: Implications for cholinergic neurotransmission

被引:48
作者
Blusztajn, JK [1 ]
Cermak, JM [1 ]
Holler, T [1 ]
Jackson, DA [1 ]
机构
[1] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA
关键词
acetylcholine; phosphatidyl choline; memory; nutrition;
D O I
10.1016/S0928-4257(98)80010-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Choline supplementation during the second half of the gestational period in rats permanently improves visuospatial memory. Choline availability during this period also alters the turnover of choline and acetylcholine in the hippocampus in 3-4-week-old animals in a complex pattern consistent with the notion that cholinergic neurotransmission is enhanced by prenatal choline supplementation. ((C)Elsevier, Paris).
引用
收藏
页码:199 / 203
页数:5
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