Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

被引：41

作者：

Egashira, Nobuaki ^{[1
,2
]}

Ishigami, Noriko ^{[2
]}

Pu, Fengling ^{[2
]}

Mishima, Kenichi ^{[2
]}

Iwasaki, Katsunori ^{[2
]}

Orito, Kensuke ^{[2
]}

Oishi, Ryozo ^{[1
]}

Fujiwara, Michihiro ^{[2
]}

机构：

[1] Kyushu Univ Hosp, Dept Pharm, Higashi Ku, Fukuoka 8128582, Japan

[2] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 01期

关键词：

gamma-glutamylethylamide; theanine; spatial memory; ischemia; neuroprotection;

D O I：

10.1002/ptr.2261

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The present study investigated the neuroprotective effect of gamma-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

收藏

页码：65 / 68

页数：4

相关论文

共 19 条

[1]

Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia [J].

Arias, RL ;

Tasse, JRP ;

Bowlby, MR .

BRAIN RESEARCH, 1999, 816 (02) :299-308

[2]

Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization [J].

Egashira, N ;

Matsumoto, Y ;

Mishima, K ;

Iwasaki, K ;

Fujioka, M ;

Matsushita, M ;

Shoyama, Y ;

Nishimura, R ;

Fujiwara, M .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 83 (01) :161-167

[3]

Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice [J].

Egashira, N ;

Hayakawa, K ;

Mishima, K ;

Kimura, H ;

Iwasaki, K ;

Fujiwara, M .

NEUROSCIENCE LETTERS, 2004, 363 (01) :58-61

[4]

Selective γ-aminobutyric acid type A receptor antagonism reverses isofurane ischemic neuroprotection [J].

Elsersy, Hazem ;

Mixco, Javier ;

Sheng, Huaxin ;

Pearlstein, Robert D. ;

Warner, David S. .

ANESTHESIOLOGY, 2006, 105 (01) :81-90

[5]

Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors [J].

Ito, H ;

Watanabe, Y ;

Isshiki, A ;

Uchino, H .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1999, 43 (02) :153-162

[6]

Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats [J].

Iwasaki, K ;

Chung, EH ;

Egashira, E ;

Hatip-Al-Khatib, I ;

Mishima, K ;

Egawa, T ;

Irie, K ;

Fujiwara, M .

BRAIN RESEARCH, 2004, 995 (01) :131-139

[7]

Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors [J].

Kakuda, T ;

Nozawa, A ;

Sugimoto, A ;

Niino, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (12) :2683-2686

[8]

Protective effect of γ-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils [J].

Kakuda, T ;

Yanase, H ;

Utsunomiya, K ;

Nozawa, A ;

Unno, T ;

Kataoka, K .

NEUROSCIENCE LETTERS, 2000, 289 (03) :189-192

[9]

YM90K, an AMPA receptor antagonist, protects against ischemic damage caused by permanent and transient middle cerebral artery occlusion in rats [J].

Kawasaki-Yatsugi, S ;

Ichiki, C ;

Yatsugi, S ;

Shimizu-Sasamata, M ;

Yamaguchi, T .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (05) :586-591

[10]

Neuroprotective effect of YM90K, an AMPA-receptor antagonist, against delayed neuronal death induced by transient global cerebral ischemia in gerbils and rats [J].

KawasakiYatsugi, S ;

Yatsugi, S ;

Koshiya, K ;

ShimizuSasamata, M .

JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 74 (03) :253-260