The Dietary Approaches to Stop Hypertension Eating Plan Affects C-Reactive Protein, Coagulation Abnormalities, and Hepatic Function Tests among Type 2 Diabetic Patients

被引:145
作者
Azadbakht, Leila [1 ,2 ]
Surkan, Pamela J. [3 ]
Esmaillzadeh, Ahmad [1 ,2 ]
Willett, Walter C. [4 ,5 ]
机构
[1] Isfahan Univ Med Sci, Sch Publ Hlth, Food Secur Res Ctr, Esfahan 81745, Iran
[2] Isfahan Univ Med Sci, Sch Publ Hlth, Dept Nutr, Esfahan 81745, Iran
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
关键词
CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; HIGH-FIBER DIET; METABOLIC SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE; SYSTEMIC INFLAMMATION; PLASMA-FIBRINOGEN; VEGETABLE-OILS; SODIUM-INTAKE;
D O I
10.3945/jn.110.136739
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Few studies exist regarding the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on novel cardiovascular risk factors among type 2 diabetic patients. We evaluated the effects of the DASH eating pattern on C-reactive protein (CRP) level, coagulation abnormalities, and hepatic function tests in type 2 diabetic patients. In this randomized, crossover clinical trial, 31 type 2 diabetic patients consumed a control diet or the DASH diet for 8 wk. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/d sodium. The control diet was a standard diet for diabetic patients. There was a 4-wk washout between the 2 trial phases. The main outcome measures were CRP level, coagulation indices, and hepatic function tests. The mean percent change for plasma CRP level was -26.9 +/- 3.5% after the DASH diet period and -5.1 +/- 3.8% after the control diet period (P = 0.02). Decreases in both alanine aminotransferase and aspartate aminotransferase levels were greater after consuming the DASH diet compared with the control diet (-14.8 +/- 3.0% vs -6.6 +/- 3.4%; P = 0.001; -29.4 +/- 3.7% vs -5.9 +/- 1.4%; P = 0.001, respectively). The decrease in the plasma fibrinogen level during the DASH diet period (-11.4 +/- 3.6%) was greater than that during the control diet (0.5 +/- 3.4%) (P = 0.03). Among diabetic patients, the DASH diet can play an important role in reducing inflammation, plasma levels of fibrinogen, and liver aminotransferases. Future longer term studies are recommended. J. Nutr. 141: 1083-1088, 2011.
引用
收藏
页码:1083 / 1088
页数:6
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