Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats

被引：49

作者：

Akcan, Alper ^{[1
]}

Kucuk, Can ^{[1
]}

Sozuer, Erdogan ^{[1
]}

Esel, Duygu ^{[2
]}

Akyildiz, Hizir ^{[1
]}

Akgun, Hulya ^{[3
]}

Muhtaroglu, Sabahattin ^{[4
]}

Aritas, Yucel ^{[1
]}

机构：

[1] Erciyes Univ, Sch Med, Dept Gen Surg, TR-38039 Kayseri, Turkey

[2] Erciyes Univ, Sch Med, Dept Microbiol, TR-38039 Kayseri, Turkey

[3] Erciyes Univ, Sch Med, Dept Pathol, TR-38039 Kayseri, Turkey

[4] Erciyes Univ, Sch Med, Dept Biochem, TR-38039 Kayseri, Turkey

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 06期

关键词：

melatonin; colitis; bacterial translocation; apoptosis; INFLAMMATORY-BOWEL-DISEASE; MESENTERIC LYMPH-NODES; TNBS-INDUCED COLITIS; ULCERATIVE-COLITIS; EPITHELIAL-CELLS; CROHNS-DISEASE; IMMUNE-SYSTEM; MODEL; COLON; EXPRESSION;

D O I：

10.3748/wjg.14.918

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To investigate the effects of exogenous; melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS: Rats were randomly assigned to three groups: group I : control, group II : experimental colitis, group III : colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-alpha, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced incidence of bacterial translocation to the liver, spleen, mesenteric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-treated rats (16.11 +/- 2.46 vs 32.97 +/- 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on bacterial translocation and apoptosis. (C) 2008 WJG, All rights reserved.

引用

页码：918 / 924

页数：7

共 44 条

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