Apoptosis - Death deceiver

被引：53

作者：

Green, DR ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

NATURE | 1998年 / 396卷 / 6712期

关键词：

D O I：

10.1038/25248

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumours develop because the tumour cells are immortal -- they escape cell-killing mechanisms. Normally, when a molecule called Fas binds its ligand (FasL), a death pathway (apoptosis) is activated. But another molecule called DcR3, which has now been identified in lung and colon carcinomas, can also bind FasL, blocking the apoptotic pathway and allowing tumour cells to cheat death.

引用

页码：629 / 630

页数：2

共 10 条

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