Insurmountable AT1 receptor antagonism:: the need for different antagonist binding states of the receptor

被引：23

作者：

Vauquelin, G ^{[1
]}

Fierens, F ^{[1
]}

Verheijen, I ^{[1
]}

Vanderheyden, P ^{[1
]}

机构：

[1] Free Univ Brussels, Inst Mol Biol & Biotechnol, Dept Mol & Biochem Pharmacol, B-1640 Rhode St Genese, Belgium

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 07期

关键词：

D O I：

10.1016/S0165-6147(00)01739-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：343 / 344

页数：2

共 9 条

[1] Insurmountable angiotensin AT1 receptor antagonists:: the role of tight antagonist binding [J].

Fierens, FLP ;

Vanderheyden, PML ;

De Backer, JP ;

Vauquelin, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 372 (02) :199-206

[2] Non-surmountable antagonism: a general drawback of pre-steady-state measurement? [J].

Hall, D ;

Parsons, S .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (02) :63-65

[3] Dynamic mechanisms of non-classical antagonism by competitive AT1 receptor antagonists [J].

Lew, MJ ;

Ziogas, J ;

Christopoulos, A .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (10) :376-381

[4] Non-surmountable antagonism:: transcending steady state -: Response from Lew et al. [J].

Lew, MJ ;

Christopoulos, A ;

Ziogas, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (02) :65-66

[5] EVIDENCE THAT THE APPARENT COMPLEXITY OF RECEPTOR ANTAGONISM BY ANGIOTENSIN-II ANALOGS IS DUE TO A REVERSIBLE AND SYNOPTIC ACTION [J].

LIU, YJ ;

SHANKLEY, NP ;

WELSH, NJ ;

BLACK, JW .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 106 (02) :233-241

[6] AGONIST-ANTAGONIST INTERACTIONS AT ANGIOTENSIN RECEPTORS - APPLICATION OF A 2-STATE RECEPTOR MODEL [J].

ROBERTSON, MJ ;

DOUGALL, IG ;

HARPER, D ;

MCKECHNIE, KCW ;

LEFF, P .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (10) :364-369

[7] Angiotensin II type 1 receptor antagonists - Why do some of them produce insurmountable inhibition? [J].

Vanderheyden, PML ;

Fierens, FLP ;

Vauquelin, G .

BIOCHEMICAL PHARMACOLOGY, 2000, 60 (11) :1557-1563

[8] Distinctions between non-peptide angiotensin II AT1-receptor antagonists [J].

Vauquelin, G ;

Fierens, FLP ;

Verheijen, I ;

Vanderheyden, PML .

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2001, 2 :S24-S31

[9] A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists [J].

Vauquelin, G ;

Morsing, P ;

Fierens, FLP ;

De Backer, JP ;

Vanderheyden, PML .

BIOCHEMICAL PHARMACOLOGY, 2001, 61 (03) :277-284

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