Mechanisms of oxysterol-induced apoptosis

被引：107

作者：

Panini, SR ^{[1
]}

Sinensky, MS ^{[1
]}

机构：

[1] E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol, Johnson City, TN 37614 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2001年 / 12卷 / 05期

关键词：

D O I：

10.1097/00041433-200110000-00008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rationale for the present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis. This perspective is based on studies that show that induction of apoptosis in vascular cells is an important process in atherogenesis, that apoptosis can be induced by oxLDL, and that the oxysterol component of oxLDL is responsible for its proapoptotic activity. The evidence for these concepts is reviewed, as are studies on the mechanisms by which oxysterols can induce apoptosis. An elevation in intracellular calcium appears to be an early signal transduction event that leads to apoptosis through both the extrinsic and intrinsic apoptotic pathways. Curr Coin Lipidol 12:529-533., (C) 2001 Lippincott Williams & Wilkins.

引用

页码：529 / 533

页数：5

共 51 条

[1] 7β-hydroxycholesterol induces Ca2+ oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells [J].

Ares, MPS ;

Pörn-Ares, MI ;

Moses, S ;

Thyberg, J ;

Juntti-Berggren, L ;

Berggren, PO ;

Hultgårdh-Nilsson, A ;

Kallin, B ;

Nilsson, J .

ATHEROSCLEROSIS, 2000, 153 (01) :23-35

[2] Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture [J].

Bennett, MR .

CARDIOVASCULAR RESEARCH, 1999, 41 (02) :361-368

[3] The role of oxidized lipoproteins in atherogenesis [J].

Berliner, JA ;

Heinecke, JW .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (05) :707-727

[4] 7-BETA-HYDROPEROXYCHOLEST-5-EN-3-BETA-OL, A COMPONENT OF HUMAN ATHEROSCLEROTIC LESIONS, IS THE PRIMARY CYTOTOXIN OF OXIDIZED HUMAN LOW-DENSITY-LIPOPROTEIN [J].

CHISOLM, GM ;

MA, GP ;

IRWIN, KC ;

MARTIN, LL ;

GUNDERSON, KG ;

LINBERG, LF ;

MOREL, DW ;

DICORLETO, PE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11452-11456

[5] Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice [J].

Cyrus, T ;

Witztum, JL ;

Rader, DJ ;

Tangirala, R ;

Fazio, S ;

Linton, MF ;

Funk, CD .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (11) :1597-1604

[6]

Dimmeler S, 1997, CIRCULATION, V95, P1760

[7] Different apoptotic pathways mediated by Fas and the tumor-necrosis-factor receptor - Cytosolic phospholipase A(2) is not involved in Fas-mediated apoptosis [J].

Enari, M ;

Hug, H ;

Hayakawa, M ;

Ito, F ;

Nishimura, Y ;

Nagata, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 236 (02) :533-538

[8] Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells [J].

Escargueil-Blanc, I ;

Andrieu-Abadie, N ;

Caspar-Bauguil, S ;

Brossmer, R ;

Levade, T ;

Nègre-Salvayre, A ;

Salvayre, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (42) :27389-27395

[9] Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway - Prevention by aurintricarboxylic acid [J].

EscargueilBlanc, I ;

Meilhac, O ;

Pieraggi, MT ;

Arnal, JF ;

Salvayre, R ;

NegreSalvayre, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (02) :331-339

[10] NECROSIS AND APOPTOSIS INDUCED BY OXIDIZED LOW-DENSITY LIPOPROTEINS OCCUR THROUGH 2 CALCIUM-DEPENDENT PATHWAYS IN LYMPHOBLASTOID-CELLS [J].

ESCARGUEILBLANC, I ;

SALVAYRE, R ;

NEGRESALVAYRE, A .

FASEB JOURNAL, 1994, 8 (13) :1075-1080

← 1 2 3 4 5 6 →