Attachment of Mouse Hepatitis Virus to O-Acetylated Sialic Acid Is Mediated by Hemagglutinin-Esterase and Not by the Spike Protein

被引：48

作者：

Langereis, Martijn A. ^{[1
]}

van Vliet, Arno L. W. ^{[1
]}

Boot, Willemijn ^{[1
]}

de Groot, Raoul J. ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, NL-3584 CL Utrecht, Netherlands

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 17期

关键词：

INFLUENZA-C-VIRUS; TRANSMISSIBLE GASTROENTERITIS VIRUS; BOVINE CORONAVIRUS; ENCEPHALOMYELITIS VIRUS; STRUCTURAL POLYPEPTIDES; SUBSTRATE-SPECIFICITY; CONTAINING RECEPTORS; MURINE CORONAVIRUS; INFANT MICE; HE-PROTEIN;

D O I：

10.1128/JVI.00566-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The members of Betacoronavirus phylocluster A possess two types of surface projections, one comprised of the spike protein (S) and the other of hemagglutinin-esterase (HE). Purportedly, these viruses bind to O-acetylated sialic acids (O-Ac-Sias) primarily through S, with HE serving merely as receptor-destroying enzyme. Here, we show that, in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-Sias via HE exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches was accompanied by changes in HE ligand and substrate preference and in the roles of HE and S in Sia receptor usage.

引用

页码：8970 / 8974

页数：5

共 44 条

[1] CHARACTERIZATION AND ISOLATION OF STRUCTURAL POLYPEPTIDES IN HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS [J].