Direct access to CF3-propargyl amines and conversion to difluoromethyl imines

被引：62

作者：

Magueur, G ^{[1
]}

Crousse, B ^{[1
]}

Bonnet-Delpon, D ^{[1
]}

机构：

[1] Fac Pharm Paris, BioCIS, CNRS, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 13期

关键词：

trifluoromethyl aldimines; CF3-propargyl amines; difluoromethyl imines; difluoromethyl propargyl amines;

D O I：

10.1016/j.tetlet.2005.02.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoromethyl aldimines reacted with acetylides in toluene at -78 degrees C to provide propargyl amines in good yields. From a chiral trifluoromethyl aldimine, the propargyl amines were obtained with excellent diastereoselectivities (de > 98%). Trifluoromethyl propargyl amines could be further converted into difluoromethyl imines under basic conditions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2219 / 2221

页数：3

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