Sustained attention as a potential endophenotype for bipolar disorder

被引：43

作者：

Ancin, I. ^{[2
]}

Santos, J. L. ^{[3
]}

Teijeira, C.

Sanchez-Morla, E. M. ^{[3
]}

Bescos, M. J.

Argudo, I.

Torrijos, S.

Vazquez-Alvarez, B. ^{[2
]}

De La Vega, I.

Lopez-Ibor, J. J. ^{[4
]}

Barabash, A. ^{[2
,4
]}

Cabranes-Diaz, J. A. ^{[1
,4
]}

机构：

[1] Clin San Carlos Hosp, CIBERSAM, Inst Psiquiatria & Salud Mental, Dept Psychiat, Madrid 28040, Spain

[2] Clin San Carlos Hosp, Biomed Res Fdn, Madrid 28040, Spain

[3] Virgen de La Luz Hosp, Dept Psychiat, Cuenca, Spain

[4] Spanish Network Res Mental Hlth, CIBERSAM, Madrid, Spain

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2010年 / 122卷 / 03期

关键词：

bipolar disorder; neuropsychology; cognition; attention; CONTINUOUS PERFORMANCE-TEST; COGNITIVE IMPAIRMENT; EUTHYMIC PATIENTS; 1ST-DEGREE RELATIVES; WORKING-MEMORY; NEUROPSYCHOLOGICAL ENDOPHENOTYPES; SELECTIVE ATTENTION; REACTION-TIME; FOLLOW-UP; DEFICITS;

D O I：

10.1111/j.1600-0447.2009.01532.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Nowadays, it is accepted that to identify the biological basis of psychiatric illnesses it would be useful to deconstruct them into the most basic manifestations, such as cognitive deficits. The aim of this study was to set attention deficit as a stable vulnerability marker of bipolar disorder. Method: Sustained attention was evaluated by the Continuous Performance Test (DS-CPT) in 143 euthymic bipolar patients and 105 controls. To estimate the influence of clinical profile in attention, patients completed a semi-structured interview. Results: Bipolar patients showed a deficit in attention during euthymic periods. This disturbance correlated with years of evolution, age of onset and age of first hospitalisation; and was not influenced by other clinical data. Conclusion: Sustained attention may be considered as an endophenotype of the illness.

引用

页码：235 / 245

页数：11

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