Myasthenia gravis without chronic GVHD after allogeneic bone marrow transplantation

被引:18
作者
Baron, F
Sadzot, B
Wang, F
Beguin, Y
机构
[1] Univ Liege, Dept Med, Div Hematol, Liege, Belgium
[2] Univ Liege, Dept Med, Div Neurol, Liege, Belgium
[3] Univ Liege, Dept Phys Therapy, Liege, Belgium
关键词
myasthenia gravis; bone marrow transplantation; aplastic anemia;
D O I
10.1038/sj.bmt.1701297
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A 20-year-old man with aplastic anemia developed myasthenia gravis (MG) 7 months after bone marrow transplantation (BMT) from an HLA one locus-mismatched sister. Proximal muscle weakness (predominant in the lower limbs) :and dysphagia occurred without any other sign of graft-versus-host disease (GVHD), 1 month after cessation of immunosuppression with cyclosporine. The diagnosis of MG was based on clinical symptoms and on neurophysiologic investigations showing a significant increase of the Jitter in single-fiber electromyographs and a significant decremental response during repetitive stimulation at slow rates, but antibodies against the acetylcholine receptor (AchRab) were negative. All clinical and neurophysiological signs normalized within 1 month of treatment with low-dose prednisolone and pyridostigmine, and the patient is perfectly well 1 year after cessation of all therapy. All cases of BRIT-associated MG previously published are reviewed in comparison with ours. The originality of this new observation is that this case is the only one not associated with chronic GVHD and negative for AchRab, Alternatively, MG may have been the sole manifestation of chronic GVHD in this patient.
引用
收藏
页码:197 / 200
页数:4
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