The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

被引：11

作者：

Hoffman, SMG

Hromas, R

Amemiya, C

Mohrenweiser, HW

机构：

[1] INDIANA UNIV,MED CTR,WALTHER ONCOL CTR,DEPT MED,DIV HEMATOL ONCOL,INDIANAPOLIS,IN 46202

[2] LAWRENCE LIVERMORE NATL LAB,CTR HUMAN GENOME,BIOL & BIOTECHNOL RES PROGRAM,LIVERMORE,CA 94551

来源：

LEUKEMIA RESEARCH | 1996年 / 20卷 / 03期

关键词：

telomeric degeneration; MZF-1; hematopoesis;

D O I：

10.1016/0145-2126(95)00158-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：281 / 283

页数：3

共 8 条

[1] ANTISENSE OLIGONUCLEOTIDES FROM THE STAGE-SPECIFIC MYELOID ZINC FINGER GENE MZF-1 INHIBIT GRANULOPOIESIS INVITRO [J].