Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy

被引：30

作者：

He, Li ^{[1
]}

Fan, Ying ^{[1
]}

Xiao, Wenzhen ^{[1
,2
]}

Chen, Teng ^{[1
]}

Wen, Jiejun ^{[1
]}

Dong, Yang ^{[1
]}

Wang, Yiyun ^{[1
]}

Li, Shiqi ^{[1
]}

Xue, Rui ^{[1
]}

Zheng, Liyang ^{[1
]}

He, John Cijiang ^{[2
]}

Wang, Niansong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Nephrol, Shanghai, Peoples R China

[2] Icahn Sch Med Mt Sinai, Div Nephrol, Dept Med, New York, NY 10029 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 67期

基金：

中国国家自然科学基金;

关键词：

hyperuricemic nephropathy; hyperuricemia; ER stress; renal tubular cells; Febuxostat; ENDOPLASMIC-RETICULUM STRESS; URIC-ACID; XANTHINE OXIDOREDUCTASE; ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; RENAL-DISEASE; GOUT; ALLOPURINOL; INHIBITION; PROGRESSION;

D O I：

10.18632/oncotarget.22784

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression of RTN1A and ER stress markers was significantly increased in kidney biopsies of hyperuricemia patients with kidney injury. In a rat model of hyperuricemic nephropathy (HN) established by oral administration of a mixture of adenine and potassium oxonate, increased expression of RTN1A and ER stress was shown in tubular and interstitial compartment of rat kidneys. Treatment of Febuxostat, a new selective inhibitor of xanthine oxidase (XO), not only attenuated renal tubular injury and tubulointerstitial fibrosis, but also reduced uric acid crystals deposition in HN rat kidneys. In vitro, Febuxostat also reduced ER stress and apoptosis in uric acid treated tubular epithelial cells. Our data suggest that RTN1A and ER stress mediate tubular cell injury and kidney fibrosis in HN. Urate-lowering therapy (ULT) with Febuxostat attenuates uric-acid induced ER stress in renal tubular cells and the progression of HN.

引用

页码：111295 / 111308

页数：14

共 45 条

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