Interferon-β in multiple sclerosis:: altering the balance of interleukin-12 and interleukin-10?

被引：54

作者：

Karp, CL

van Boxel-Dezaire, AHH

Byrnes, AA

Nagelkerken, L

机构：

[1] Univ Cincinnati, Childrens Hosp Res Fdn, Mol Immunol Sect, Cincinnati, OH 45229 USA

[2] TNO Prevent & Hlth, Div Infect Dis & Immunol, Leiden, Netherlands

[3] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD USA

来源：

CURRENT OPINION IN NEUROLOGY | 2001年 / 14卷 / 03期

关键词：

D O I：

10.1097/00019052-200106000-00016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Interferon-beta is a remarkably pleiotropic molecule. Antiviral, pro- and antiproliferative, pro- and antiapoptotic, and complex immunoregulatory activities have all been described. The precise mechanism(s) that underlie the beneficial effects of interferon-beta in multiple sclerosis remain poorly understood; this has hindered progress in the search for more effective therapies. An increasing body of literature supports the hypothesis that interferon-beta -mediated changes in the production and activities of the immunoregulatory cytokines interleukin-12 and interleukin-10 are important to the therapeutic benefits of interferon-beta in multiple sclerosis, These data are reviewed here. Curr Opin Neurol 14:361-368. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：361 / 368

页数：8

共 83 条

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