Reactivity of [RuIII(hedtra)(H2O)] with thio-amino acids and protease inhibition

被引：8

作者：

Chatterjee, D

Sengupta, A

Mitra, A

Basak, S

Bhattacharya, R

Bhattacharyya, D

机构：

[1] Cent Mech Engn Res Inst, Chem Sect, Durgapur 713209, India

[2] Indian Inst Chem Biol, Kolkata 700032, W Bengal, India

来源：

INORGANICA CHIMICA ACTA | 2005年 / 358卷 / 10期

关键词：

kinetics substitution reaction; associative mechanism; Ru(hedtra)(H2O); thio-amino acids; cysteine protcase inhibition;

D O I：

10.1016/j.ica.2004.07.047

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of [Ru-III(hedtra)(H2O)] (hedtra = N-hydroxyethylethylenediaminetriacetate) with thio-amino acids, L (L = cysteine, N-acetyleysteine, glutathione and penicilamine), was studied kinetically. Kinetic studies were performed at different concentrations of reactants, pH and temperature. Based on the kinetic results, it is suggested that the formation of S-bound substituted product takes place in a rapid ligand dependent rate determining step. Kinetic data and activation parameters are accounted for operation of an associative mechanism and discussed in reference to the data reported earlier for edta(4-) (ethylenediaminetetraacetate) complex of ruthenium(III). Results of cysteine protease inhibition studies revealed that inhibition activities of Ru pac complexes are enzyme specific. (c) 2004 Published by Elsevier B.V.

引用

页码：2960 / 2965

页数：6

共 29 条

[1] KINETICS AND MECHANISM OF THE LIGAND SUBSTITUTION-REACTIONS OF N-(HYDROXYETHYL)ETHYLENEDIAMINETRIACETATE COMPLEXES OF RUTHENIUM(III) IN AQUEOUS-SOLUTION [J].