Piezoelectric materials mimic the function of the cochlear sensory epithelium

被引:106
作者
Inaoka, Takatoshi [1 ]
Shintaku, Hirofumi [2 ]
Nakagawa, Takayuki [1 ]
Kawano, Satoyuki [2 ]
Ogita, Hideaki [1 ]
Sakamoto, Tatsunori [1 ]
Hamanishi, Shinji [3 ]
Wada, Hiroshi [4 ]
Ito, Juichi [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto 6068507, Japan
[2] Osaka Univ, Grad Sch Engn Sci, Dept Mech Sci & Bioengn, Osaka 5608531, Japan
[3] Sendai Natl Coll Technol, Dept Mech Engn, Sendai, Miyagi 9811239, Japan
[4] Tohoku Univ, Grad Sch Engn, Dept Bioengn & Robot, Sendai, Miyagi 9808579, Japan
关键词
cochlear implant; hearing loss; mechanoelectrical transduction; traveling wave; regeneration; OUTER HAIR-CELLS; GUINEA-PIG; PHYSICAL MODEL; PRESTIN; EAR; ELECTROMOTILITY; FEEDBACK;
D O I
10.1073/pnas.1110036108
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cochlear hair cells convert sound vibration into electrical potential, and loss of these cells diminishes auditory function. In response to mechanical stimuli, piezoelectric materials generate electricity, suggesting that they could be used in place of hair cells to create an artificial cochlear epithelium. Here, we report that a piezoelectric membrane generated electrical potentials in response to sound stimuli that were able to induce auditory brainstem responses in deafened guinea pigs, indicating its capacity to mimic basilar membrane function. In addition, sound stimuli were transmitted through the external auditory canal to a piezoelectric membrane implanted in the cochlea, inducing it to vibrate. The application of sound to the middle ear ossicle induced voltage output from the implanted piezoelectric membrane. These findings establish the fundamental principles for the development of hearing devices using piezoelectric materials, although there are many problems to be overcome before practical application.
引用
收藏
页码:18390 / 18395
页数:6
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