α-substituted α-lithiated oxiranes:: Useful reactive intermediates

A review on α-metallated oxiranes regarding its generation, reactivity, and synthetic applications is given with a special attention on α-lithiated oxiranes. The chemistry of this oxiranes has led to the advancement of their use in organic synthesis. Researchers are continuing to do some work with the chemistry of lithiated oxiranes to reveal new reaction pathways and develop them into synthetically useful processes. The use of stabilized α-lithiated epoxides as nucleophiles has seen significant achievements over the last ten years where it has given access to polyfunctionalized epoxides and products that can be derived from it.