Meta-analysis of genome-wide association studies for personality

被引：203

作者：

de Moor, M. H. M. ^{[1
]}

Costa, P. T. ^{[2
]}

Terracciano, A. ^{[2
]}

Krueger, R. F. ^{[3
]}

de Geus, E. J. C. ^{[1
]}

Toshiko, T. ^{[2
]}

Penninx, B. W. J. H. ^{[4
,5
,6
,7
]}

Esko, T. ^{[8
,9
,10
]}

Madden, P. A. F. ^{[11
]}

Derringer, J. ^{[3
]}

Amin, N. ^{[12
]}

Willemsen, G. ^{[1
]}

Hottenga, J-J ^{[1
]}

Distel, M. A. ^{[1
]}

Uda, M. ^{[13
]}

Sanna, S. ^{[13
]}

Spinhoven, P. ^{[5
,6
]}

Hartman, C. A. ^{[4
]}

Sullivan, P. ^{[14
]}

Realo, A. ^{[15
]}

Allik, J. ^{[15
]}

Heath, A. C. ^{[11
]}

Pergadia, M. L. ^{[11
]}

Agrawal, A. ^{[11
]}

Lin, P. ^{[11
]}

Grucza, R. ^{[11
]}

Nutile, T. ^{[16
]}

Ciullo, M. ^{[16
]}

Rujescu, D. ^{[17
]}

Giegling, I. ^{[17
]}

Konte, B. ^{[17
]}

Widen, E. ^{[18
]}

Cousminer, D. L. ^{[18
]}

Eriksson, J. G. ^{[19
,20
,21
,22
,23
]}

Palotie, A. ^{[18
,24
,25
,26
,27
]}

Peltonen, L. ^{[18
,24
,25
,26
,27
]}

Luciano, M. ^{[28
]}

Tenesa, A. ^{[29
]}

Davies, G. ^{[28
]}

Lopez, L. M. ^{[28
]}

Hansell, N. K. ^{[30
]}

Medland, S. E. ^{[30
]}

Ferrucci, L. ^{[2
]}

Schlessinger, D. ^{[2
]}

Montgomery, G. W. ^{[30
]}

Wright, M. J. ^{[30
]}

Aulchenko, Y. S. ^{[12
]}

Janssens, A. C. J. W. ^{[12
]}

Oostra, B. A. ^{[31
]}

Metspalu, A. ^{[8
,9
,10
]}

机构：

[1] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

[2] NIA, NIH, Baltimore, MD 21224 USA

[3] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands

[5] Leiden Univ, Dept Clin Psychol, Leiden, Netherlands

[6] Leiden Univ, Dept Psychiat, Leiden, Netherlands

[7] VU Univ Med Ctr Amsterdam, EMGO Inst, Dept Psychiat, Amsterdam, Netherlands

[8] Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia

[9] Estonian Bioctr, Tartu, Estonia

[10] Univ Tartu, Estonian Genome Project, EE-50090 Tartu, Estonia

[11] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[12] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[13] CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy

[14] Univ N Carolina, Dept Genet, Chapel Hill, NC USA

[15] Univ Tartu, Dept Psychol, EE-50090 Tartu, Estonia

[16] A Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy

[17] Univ Munich LMU, Dept Psychiat, Munich, Germany

[18] Univ Helsinki, FIMM, Helsinki, Finland

[19] Natl Inst Hlth & Welf, Helsinki, Finland

[20] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[21] Vasa Cent Hosp, Vaasa, Finland

[22] Univ Helsinki, Cent Hosp, Unit Gen Practice, Helsinki, Finland

[23] Folkhalsan Res Ctr, Helsinki, Finland

[24] Wellcome Trust Sanger Inst, Cambridge, England

[25] Broad Inst Harvard & MIT, Cambridge, MA USA

[26] Univ Helsinki, Dept Med Genet, Helsinki, Finland

[27] Helsinki Univ Hosp, Helsinki, Finland

[28] Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland

[29] Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[30] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[31] Erasmus Univ, Dept Clin Genet, Med Ctr, NL-3000 DR Rotterdam, Netherlands

[32] Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

[33] Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland

来源：

MOLECULAR PSYCHIATRY | 2012年 / 17卷 / 03期

基金：

英国经济与社会研究理事会; 英国医学研究理事会; 英国生物技术与生命科学研究理事会; 芬兰科学院; 澳大利亚研究理事会; 英国惠康基金; 美国国家卫生研究院;

关键词：

personality; Five-Factor Model; genome-wide association; meta-analysis; genetic variants; NETHERLANDS TWIN REGISTER; MAJOR DEPRESSIVE DISORDER; NEO-PI-R; 5-FACTOR MODEL; LINKAGE ANALYSIS; QUANTITATIVE-TRAIT; ADOLESCENT TWIN; NEUROTICISM; GROWTH; GENE;

D O I：

10.1038/mp.2010.128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of similar to 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P = 2.8 x 10(-8) and 3.1 x 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P = 4.9 x 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness. Molecular Psychiatry (2012) 17, 337-349; doi: 10.1038/mp.2010.128; published online 21 December 2010

引用

页码：337 / 349

页数：13

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