Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats

被引：49

作者：

Abdallah, Hossam M. ^{[1
,2
]}

Salama, Maha M. ^{[2
]}

Abd-Elrahman, Enas H. ^{[2
]}

El-Maraghy, Shohda A. ^{[3
]}

机构：

[1] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod, Jeddah 21589, Saudi Arabia

[2] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[3] Cairo Univ, Fac Pharm, Dept Biochem, Cairo 11562, Egypt

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

关键词：

Pecan bark; Aldose reductase; Methoxy flavonoids; Sulphated flavonoids; Antidiabetic; ALDOSE REDUCTASE INHIBITOR; FLAVONOIDS; LENS;

D O I：

10.1016/j.phytol.2011.07.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3' sulfate (6) and caryatin-3' methyl ether-7-O-beta-D-glucoside (7) while five known phenolics (1-5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except 5 and 6. A marked AR-inhibitory effect was identified for compounds 2, 3 and 7. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：337 / 341

页数：5

共 29 条

[1]

Abdelrahman E.H., 2008, AZHAR J BIOMED SCI, V28, P222

[2]

Agrawal P.K., 1989, 13C NMR FLAVONOIDS, P283

[3]

Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals [J].

Amresh, G. ;

Zeashan, Hussain ;

Gupta, Ram Ji ;

Kant, Ravi ;

Rao, Chandana Venkateswara ;

Singh, Paras Nath .

JOURNAL OF NATURAL MEDICINES, 2007, 61 (03) :323-328

[4]

Bailey LH, 1953, STANDARD CYCLOPEDIA

[5]

SULFATED FLAVONOIDS - AN UPDATE [J].

BARRON, D ;

VARIN, L ;

IBRAHIM, RK ;

HARBORNE, JB ;

WILLIAMS, CA .

PHYTOCHEMISTRY, 1988, 27 (08) :2375-2395

[6]

BEUTLER E, 1963, J LAB CLIN MED, V61, P882

[7]

RENAL SORBITOL ACCUMULATION AND ASSOCIATED ENZYME-ACTIVITIES IN DIABETES [J].

CHAUNCEY, B ;

LEITE, MV ;

GOLDSTEIN, L .

ENZYME, 1988, 39 (04) :231-234

[8]

Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols [J].

Chethan, S. ;

Dharmesh, Shylaja M. ;

Malleshi, Nagappa G. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (23) :10085-10090

[9]

Cuong NM, 1996, PHARMAZIE, V51, P128

[10]

Aldose reductase and the role of the polyol pathway in diabetic nephropathy [J].

Dunlop, M .

KIDNEY INTERNATIONAL, 2000, 58 :S3-S12

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