Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: A multimodality investigation

被引：196

作者：

van Schooneveld, Matti M. ^{[3
]}

Vucic, Esad ^{[1
,2
]}

Koole, Rolf ^{[3
]}

Zhou, Yu ^{[1
,2
]}

Stocks, Joanne ^{[5
]}

Cormode, David P. ^{[1
,2
]}

Tang, Cheuk Y. ^{[1
,2
]}

Gordon, Ronald E. ^{[4
]}

Nicolay, Klaas ^{[6
]}

Meijerink, Andries ^{[3
]}

Fayad, Zahi A. ^{[1
,2
]}

Mulder, Willem J. M. ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Sinai Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Imaging Sci Labs, New York, NY 10029 USA

[3] Univ Utrecht, NL-3508 TA Utrecht, Netherlands

[4] Mt Sinai Hosp, Dept Pathol, EM Facil, New York, NY 10029 USA

[5] Mt Sinai Sch Med, Cardiovasc Res Ctr, New York, NY 10029 USA

[6] Eindhoven Univ Technol, Biomed NMR, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

来源：

NANO LETTERS | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1021/nl801596a

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.

引用

页码：2517 / 2525

页数：9

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