Sixteen Japanese nonsyndromic autosomal dominant sensorineural hearing loss (ADSNHL) families were investigated clinically as well as genetically. Most families showed postlingual hearing loss. Although the severity of their hearing loss varied, most patients showed mild-moderate sensorineural hearing loss of a progressive nature. Mutation analysis was performed fur the MYO7A, KCNQ4, and GJB3 genes, which are known to be responsible for autosomal dominant sensorineural hearing loss. The present study reports that a mutation in KCNQ4, a member of a large family of potassium channel genes, was responsible for ADSNHL in one Japanese family.
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Fukushima, K
Kasai, N
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Kasai, N
Ueki, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Ueki, Y
Nishizaki, K
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Nishizaki, K
Sugata, K
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Sugata, K
Hirakawa, S
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Hirakawa, S
Masuda, A
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Masuda, A
Gunduz, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Gunduz, M
Ninomiya, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Ninomiya, Y
Masuda, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Masuda, Y
Sato, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Sato, M
McGuirt, WT
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
McGuirt, WT
Coucke, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Coucke, P
Van Camp, G
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Van Camp, G
Smith, RJH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USAUniv Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Kelley, PM
Harris, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Harris, DJ
Comer, BC
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Comer, BC
Askew, JW
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Askew, JW
Fowler, T
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Fowler, T
Smith, SD
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Smith, SD
Kimberling, WJ
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Fukushima, K
Kasai, N
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Kasai, N
Ueki, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Ueki, Y
Nishizaki, K
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Nishizaki, K
Sugata, K
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Sugata, K
Hirakawa, S
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Hirakawa, S
Masuda, A
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Masuda, A
Gunduz, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Gunduz, M
Ninomiya, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Ninomiya, Y
Masuda, Y
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Masuda, Y
Sato, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Sato, M
McGuirt, WT
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
McGuirt, WT
Coucke, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Coucke, P
Van Camp, G
论文数: 0引用数: 0
h-index: 0
机构:Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
Van Camp, G
Smith, RJH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USAUniv Iowa, Dept Otolaryngol, Mol Otolaryngol Res Labs, Dept Otolaryngol, Iowa City, IA 52242 USA
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Kelley, PM
Harris, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Harris, DJ
Comer, BC
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Comer, BC
Askew, JW
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Askew, JW
Fowler, T
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Fowler, T
Smith, SD
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA
Smith, SD
Kimberling, WJ
论文数: 0引用数: 0
h-index: 0
机构:
Boys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USABoys Town Natl Res Hosp, Ctr Study Hereditary Hearing Loss, Omaha, NE 68131 USA