Association of vitamin D receptor genotype with leprosy type

被引:161
作者
Roy, S
Frodsham, A
Saha, B
Hazra, SK
Mascie-Taylor, CGN
Hill, AVS
机构
[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[2] Univ Cambridge, Dept Biol Anthropol, Cambridge CB2 3DZ, England
[3] Sch Trop Med, Dept Leprol, Kolkata, W Bengal, India
基金
英国惠康基金;
关键词
D O I
10.1086/314536
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Host genetic factors including major histocompatibility complex (MHC) polymorphisms influence both susceptibility to leprosy per se and also to leprosy type. Non-h IHC genes may play an important role, but such genes remain undefined. The influence of two non-MHC candidate genes was assessed in a case-control study of Bengali leprosy patients from Calcutta, Recent studies have implicated variation in the vitamin D receptor (VDR) gene in susceptibility to several diseases, including osteoporosis and pulmonary tuberculosis, In this population, homozygotes for the alternate alleles of the VDR polymorphism are associated, respectively, with lepromatous and tuberculoid leprosy. The NRAMP1 (natural resistance associated macrophage protein 1) gene may influence human mycobacterial disease susceptibility based on studies with the murine homologue Nramp1. However, no significant association was found between NRAMP1 and leprosy susceptibility, This study suggests that the VDR polymorphism may influence susceptibility to some diseases by affecting the type and the strength of the host immune response.
引用
收藏
页码:187 / 191
页数:5
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