Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients

被引：105

作者：

Sarchielli, P

Alberti, A

Floridi, A

Gallai, V

机构：

[1] Univ Perugia, Monteluce Policlin, Dept Neurosci, Dept Internal Med, I-06126 Perugia, Italy

[2] Univ Perugia, Monteluce Policlin, Lab Clin Biochem, Dept Internal Med, Perugia, Italy

来源：

NEUROLOGY | 2001年 / 57卷 / 01期

关键词：

D O I：

10.1212/WNL.57.1.132

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nerve growth factor (NGF) levels were determined in the CSF of patients with chronic daily headache (CDH) and correlated with levels of sensory neuropeptides. Patients with CDH showed higher NGF levels in the CSF compared with control subjects (p < 0.0001). Higher CSF levels of substance P (SP) (p < 0.002) and calcitonin-gene-related peptide (CGRP) (p < 0.0001) were also found. There was a significant positive correlation between NG-F and both SP and CGRP values. These findings suggest that NGF is involved in the long-lasting sensitization and sustained activation of the trigeminal system in CDH.

引用

页码：132 / 134

页数：3

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