MEIS homeobox genes in neuroblastoma

被引：25

作者：

Geerts, D ^{[1
]}

Revet, I ^{[1
]}

Jorritsma, G ^{[1
]}

Schilderink, N ^{[1
]}

Versteeg, R ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Human Genet M1 131, NL-1105 AZ Amsterdam, Netherlands

来源：

CANCER LETTERS | 2005年 / 228卷 / 1-2期

关键词：

homeobox; MEIS; neuroblastoma; signal transduction; signaling network; TALE;

D O I：

10.1016/j.canlet.2005.01.047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

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页码：43 / 50

页数：8

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