Tacrine and donepezil attenuate the neurotoxic effect of Aβ(25-35) in rat PC12 cells

被引：71

作者：

Svensson, AL ^{[1
]}

Nordberg, A ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Clin Neurosci & Family Med, Div Mol Neuropharmacol, S-14186 Huddinge, Sweden

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

beta-amyloid(25-35); donepezil; neuroprotection; nicotinic receptors; PC12; cells; tacrine;

D O I：

10.1097/00001756-199805110-00050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effect of the cholinesterase inhibitors tacrine and donepezil on A beta(25-35)-induced toxicity was investigated in rat pheochromocytoma PC12 cells by measuring the mitochondrial activity. Tacrine and donepezil was found in clinical relevant concentrations (10(-7)-10(-6) M) to attenuate A beta(25-35)-induced toxicity in PC12 cells. The neuroprotective effect of tacrine was blocked in the presence of the nicotinic antagonists mecamylamine (10(-5) M) and tubocurarine (10(-5)M), suggesting an interaction via nicotinic receptors. This study demonstrates that tacrine and donepezil can exert neuroprotective properties which might be of importance and contribute to the clinical efficacy of cholinesterase inhibitors in the treatment of Alzheimer's disease. (C) 1998 Rapid Science Ltd.

引用

页码：1519 / 1522

页数：4

共 35 条

[1]

AHE K, 1996, J NEUROCHEM, V67, P2074

[2] NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY [J].